TY - JOUR
T1 - Micronucleus formation induced in rat liver and esophagus by nitrosamines
AU - Mehta, Rekha
AU - Silinskas, K. Charles
AU - Zucker, Peter F.
AU - Ronen, Amiram
AU - Heddle, John A.
AU - Archer, Michael C.
PY - 1987/6
Y1 - 1987/6
N2 - The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.
AB - The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.
UR - http://www.scopus.com/inward/record.url?scp=0023359607&partnerID=8YFLogxK
U2 - 10.1016/0304-3835(87)90133-9
DO - 10.1016/0304-3835(87)90133-9
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C2 - 3594426
AN - SCOPUS:0023359607
SN - 0304-3835
VL - 35
SP - 313
EP - 320
JO - Cancer Letters
JF - Cancer Letters
IS - 3
ER -