Micronucleus formation induced in rat liver and esophagus by nitrosamines

Rekha Mehta, K. Charles Silinskas, Peter F. Zucker, Amiram Ronen, John A. Heddle, Michael C. Archer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.

Original languageEnglish
Pages (from-to)313-320
Number of pages8
JournalCancer Letters
Volume35
Issue number3
DOIs
StatePublished - Jun 1987

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