Micronucleus formation induced in rat liver and esophagus by nitrosamines

Rekha Mehta; K. Charles Silinskas; Peter F. Zucker; Amiram Ronen; John A. Heddle; Michael C. Archer

doi:10.1016/0304-3835(87)90133-9

Micronucleus formation induced in rat liver and esophagus by nitrosamines

Rekha Mehta
, K. Charles Silinskas
, Peter F. Zucker
, Amiram Ronen
, John A. Heddle
, Michael C. Archer^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.

Original language	English
Pages (from-to)	313-320
Number of pages	8
Journal	Cancer Letters
Volume	35
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(87)90133-9
State	Published - Jun 1987

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title = "Micronucleus formation induced in rat liver and esophagus by nitrosamines",

abstract = "The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.",

author = "Rekha Mehta and Silinskas, \{K. Charles\} and Zucker, \{Peter F.\} and Amiram Ronen and Heddle, \{John A.\} and Archer, \{Michael C.\}",

year = "1987",

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AU - Mehta, Rekha

AU - Silinskas, K. Charles

AU - Zucker, Peter F.

AU - Ronen, Amiram

AU - Heddle, John A.

AU - Archer, Michael C.

PY - 1987/6

Y1 - 1987/6

N2 - The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.

AB - The rat hepatocarcinogen nitrosodimethylamine and the esophageal carcinogens nitrosomethylbenzylamine and nitrosomethylamylamine were shown to produce chromosomal damage, as manifested by micronucleus formation, in their target tissues. There was cross-reactivity in the two tissues, however, at high dose levels. Nitrosodiethylamine, which produces tumors in both the liver and esophagus in the rat, also produced micronuclei in both tissues.

UR - https://www.scopus.com/pages/publications/0023359607

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Micronucleus formation induced in rat liver and esophagus by nitrosamines

Abstract

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