Abstract
Traditional treatment of open wounds engaged bandages such as gauze of cotton, wool or lint with the primary function to keep the wound dry. Findings now show that proper natural or synthetic biomaterials achieve rapid wound healing by preventing desiccation. Hydrogels, ie, a network of hydrophilic polymer chains with water dispersed inside the network, provide an excellent system for wound healing. Polymers, be they from natural origins (eg, polysaccharides and proteoglycans) or synthetic (eg, polyglycolic acid, polylactic acid, polyacrylic acid, poly-?-caprolactone, polyvinyl pyrrolidone, polyvinyl alcohol and polyethylene glycol) exhibit wound healing properties. Micro- and nanoparticulate delivery systems designed with these polymers have also been applied for wound healing. Furthermore, delivering polystyrene particles to the wound surface to induce an inflammatory response is a new concept. This chapter offers an overview of polymer and hydrogels as well as the various novel delivery systems for wound healing with advancements in patents, clinical trials and marketed products.
| Original language | English |
|---|---|
| Title of host publication | Functional Biomaterials |
| Publisher | Elsevier Inc. |
| Pages | 203-225 |
| Number of pages | 23 |
| Volume | 2 |
| ISBN (Electronic) | 9780081006061 |
| ISBN (Print) | 9781782424567 |
| DOIs | |
| State | Published - 1 Jun 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Elsevier Ltd All rights reserved.
Keywords
- Hydrogel
- Microparticles
- Nanoparticles
- Natural polymers
- Synthetic polymers
- Wound healing