TY - JOUR
T1 - Microstructural proliferation in human cortex is coupled with the development of face processing
AU - Gomez, Jesse
AU - Barnett, Michael A.
AU - Natu, Vaidehi
AU - Mezer, Aviv
AU - Palomero-Gallagher, Nicola
AU - Weiner, Kevin S.
AU - Amunts, Katrin
AU - Zilles, Karl
AU - Grill-Spector, Kalanit
N1 - Publisher Copyright:
© 2016 by the American Association for the Advancement of Science; all rights reserved.
PY - 2017/1/6
Y1 - 2017/1/6
N2 - How does cortical tissue change as brain function and behavior improve from childhood to adulthood? By combining quantitative and functional magnetic resonance imaging in children and adults, we find differential development of high-level visual areas that are involved in face and place recognition. Development of face-selective regions, but not place-selective regions, is dominated by microstructural proliferation. This tissue development is correlated with specific increases in functional selectivity to faces, as well as improvements in face recognition, and ultimately leads to differentiated tissue properties between face- and place-selective regions in adulthood, which we validate with postmortem cytoarchitectonic measurements. These data suggest a new model by which emergent brain function and behavior result from cortical tissue proliferation rather than from pruning exclusively.
AB - How does cortical tissue change as brain function and behavior improve from childhood to adulthood? By combining quantitative and functional magnetic resonance imaging in children and adults, we find differential development of high-level visual areas that are involved in face and place recognition. Development of face-selective regions, but not place-selective regions, is dominated by microstructural proliferation. This tissue development is correlated with specific increases in functional selectivity to faces, as well as improvements in face recognition, and ultimately leads to differentiated tissue properties between face- and place-selective regions in adulthood, which we validate with postmortem cytoarchitectonic measurements. These data suggest a new model by which emergent brain function and behavior result from cortical tissue proliferation rather than from pruning exclusively.
UR - http://www.scopus.com/inward/record.url?scp=85009265645&partnerID=8YFLogxK
U2 - 10.1126/science.aag0311
DO - 10.1126/science.aag0311
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C2 - 28059764
AN - SCOPUS:85009265645
SN - 0036-8075
VL - 355
JO - Science
JF - Science
IS - 6320
M1 - aag0311
ER -