Large-scale Molecular Dynamics (MD) studies on heterogeneous, model metal systems subjected to intense shock loading by a flyer plate were carried out. Of interest here is the effect of structural defects on interfacial strength under these extreme conditions. The metal target and flyer were essentially single crystals of Cu, but an interface layer was created by varying the mass of the Cu atoms in part of the sample. Interfacial defects in the form of vacancies, and at different concentrations, were introduced into the interfacial region. In addition to microstructural evolution of damage in this system, the shock induced temperature and pressure changes were also analyzed.