Migration cues induce chromatin alterations

Gabi Gerlitz; Idit Livnat; Carmit Ziv; Oded Yarden; Michael Bustin; Orly Reiner

doi:10.1111/j.1600-0854.2007.00638.x

Migration cues induce chromatin alterations

Gabi Gerlitz, Idit Livnat, Carmit Ziv, Oded Yarden, Michael Bustin, Orly Reiner^*

^*Corresponding author for this work

Department of Plant Pathology and Microbiology

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

Directed cell migration is a property central to multiple basic biological processes. Here, we show that directed cell migration is associated with global changes in the chromatin fiber. Polarized posttranslational changes in histone H1 along with a transient decrease in H1 mobility were detected in cells facing the scratch in a wound healing assay. In parallel to the changes in H1, the levels of the heterochromatin marker histone H3 lysine 9 tri-methylation were elevated. Interestingly, reduction of the chromatin-binding affinity of H1 altered the cell migration rates. Moreover, migration-associated changes in histone H1 were observed during nuclear motility in the simple multicellular organism Neurospora crassa . Our studies suggest that dynamic reorganization of the chromatin fiber is an early event in the cellular response to migration cues.

Original language	English
Pages (from-to)	1521-1529
Number of pages	9
Journal	Traffic
Volume	8
Issue number	11
DOIs	https://doi.org/10.1111/j.1600-0854.2007.00638.x
State	Published - Nov 2007

Keywords

Chromatin
Histone H1
Histone modifications
Migration

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10.1111/j.1600-0854.2007.00638.x

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AU - Livnat, Idit

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AU - Yarden, Oded

AU - Bustin, Michael

AU - Reiner, Orly

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AB - Directed cell migration is a property central to multiple basic biological processes. Here, we show that directed cell migration is associated with global changes in the chromatin fiber. Polarized posttranslational changes in histone H1 along with a transient decrease in H1 mobility were detected in cells facing the scratch in a wound healing assay. In parallel to the changes in H1, the levels of the heterochromatin marker histone H3 lysine 9 tri-methylation were elevated. Interestingly, reduction of the chromatin-binding affinity of H1 altered the cell migration rates. Moreover, migration-associated changes in histone H1 were observed during nuclear motility in the simple multicellular organism Neurospora crassa . Our studies suggest that dynamic reorganization of the chromatin fiber is an early event in the cellular response to migration cues.

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Migration cues induce chromatin alterations

Abstract

Keywords

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