Migration of adhesive and nonadhesive particles in the rat intestine under altered mucus secretion conditions

Boaz Tirosh, Abraham Rubinstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


The migration rate of adhesive (polycarbophil) and nonadhesive (Eudragit RL-100) particles was studied in the small and large intestine of the anesthetized rat under altered mucus secretion conditions accomplished by cholinergic stimulation (a previously developed in situ model which distinctly accounts for the effect of regional changes in mucus turnover rate on mucoadhesion in the digestive tube of the rat). It was found that in the proximal jejunum the relative recovery time (RRT) of adhesive particles, but not nonadhesive particles, was decreased by carbachol stimulation. However, adhesive particles agglomerated a short while alter their administration into this organ. In the colon RRT of both adhesive and nonadhesive particles decreased in a similar manner as the mucus secretion increased. It is concluded that, in the rat, interactions between intestinal mucus layer and adhesive and nonadhesive particles are similar. The corresponding similarity in the intestinal transit time for both types of particles raises doubts about the advantage of nonspecific adherence in the design of oral prolonged- release dosage forms.

Original languageAmerican English
Pages (from-to)453-456
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number4
StatePublished - Apr 1998

Bibliographical note

Funding Information:
The study was supported by a research grant (no. 4550) from the Joint Research Center of the EC Commission for Science and R&D and the Israeli Ministry of Science and Art. The helpful discussions and comments of Professor Claus Michael Lehr, Universität des Saarlandes, Germany, and Professor Jindrich Kopecek, University of Utah, during the preparation of this manuscript are greatly appreciated.


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