Miklós Bodanszky Award Lecture: Selective chalcogen chemistry to study protein science

Norman Metanis*, Rebecca Notis Dardashti, Reem Mousa, Orit Weil-Ktorza

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In recent decades, chemical protein synthesis and the development of chemoselective reactions—including ligation reactions—have led to significant breakthroughs in protein science. Among them are a better understanding of protein structure-function relationships, the study of protein posttranslational modifications, exploration of protein design, unnatural amino acid incorporation, and the study of therapeutic proteins and protein folding. Chalcogen chemistry, especially that of sulfur and selenium, is quite rich, and we have witnessed continuous progress in this field in recent years. In this short review, we will instead summarize three stories that we have recently presented on chalcogen chemistry and its impact on protein science, which was presented in the Miklós Bodanszky Award Lecture at the 35th European Peptide Society Meeting in Dublin, Ireland, 26 August 2018.

Original languageAmerican English
Article numbere3204
JournalJournal of Peptide Science
Volume25
Issue number9
DOIs
StatePublished - Sep 2019

Bibliographical note

Publisher Copyright:
© 2019 European Peptide Society and John Wiley & Sons, Ltd.

Keywords

  • chemical protein synthesis
  • insulin
  • methylene thioacetal
  • oxidative folding
  • selenocysteine
  • selenoproteins

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