Abstract
Effective chlorination of 2,3,5,6-tetrachloropyridine to pentachloropyridine was realized under mild phase transfer conditions with carbon tetrachloride and 50% NaOH or solid K3PO4. Mechanistic study of this reaction indicated the possibility of an aromatic carbanionic intermediate. Hexachloroethane was established as a more selective electrophilic chlorination agent.
Original language | English |
---|---|
Pages (from-to) | 5061-5063 |
Number of pages | 3 |
Journal | Tetrahedron Letters |
Volume | 45 |
Issue number | 26 |
DOIs | |
State | Published - 21 Jun 2004 |
Keywords
- Aromatic carbanion
- Halogenation
- Phase transfer
- Polyhalomethane
- Potassium phosphate