miR-15 and miR-16 induce apoptosis by targeting BCL2

Amelia Cimmino; George Adrian Calin; Muller Fabbri; Marilena V. Iorio; Manuela Ferracin; Masayoshi Shimizu; Sylwia E. Wojcik; Rami I. Aqeilan; Simona Zupo; Mariella Dono; Laura Rassenti; Hansjuerg Alder; Stefano Volinia; Chang Gong Liu; Thomas J. Kipps; Massimo Negrini; Carlo M. Croce

doi:10.1073/pnas.0506654102

miR-15 and miR-16 induce apoptosis by targeting BCL2

Amelia Cimmino
, George Adrian Calin
, Muller Fabbri
, Marilena V. Iorio
, Manuela Ferracin
, Masayoshi Shimizu
, Sylwia E. Wojcik
, Rami I. Aqeilan
, Simona Zupo
, Mariella Dono
, Laura Rassenti
, Hansjuerg Alder
, Stefano Volinia
, Chang Gong Liu
, Thomas J. Kipps
, Massimo Negrini
, Carlo M. Croce^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3325 Scopus citations

Abstract

Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.

Original language	English
Pages (from-to)	13944-13949
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	102
Issue number	39
DOIs	https://doi.org/10.1073/pnas.0506654102
State	Published - 27 Sep 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Leukemia
MicroRNAs
Translation

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10.1073/pnas.0506654102

Cite this

Cimmino, A., Calin, G. A., Fabbri, M., Iorio, M. V., Ferracin, M., Shimizu, M., Wojcik, S. E., Aqeilan, R. I., Zupo, S., Dono, M., Rassenti, L., Alder, H., Volinia, S., Liu, C. G., Kipps, T. J., Negrini, M., & Croce, C. M. (2005). miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America, 102(39), 13944-13949. https://doi.org/10.1073/pnas.0506654102

@article{9687f61b60c7469db09e49c41a188aba,

title = "miR-15 and miR-16 induce apoptosis by targeting BCL2",

abstract = "Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.",

keywords = "Leukemia, MicroRNAs, Translation",

author = "Amelia Cimmino and Calin, \{George Adrian\} and Muller Fabbri and Iorio, \{Marilena V.\} and Manuela Ferracin and Masayoshi Shimizu and Wojcik, \{Sylwia E.\} and Aqeilan, \{Rami I.\} and Simona Zupo and Mariella Dono and Laura Rassenti and Hansjuerg Alder and Stefano Volinia and Liu, \{Chang Gong\} and Kipps, \{Thomas J.\} and Massimo Negrini and Croce, \{Carlo M.\}",

year = "2005",

month = sep,

day = "27",

doi = "10.1073/pnas.0506654102",

language = "אנגלית",

volume = "102",

pages = "13944--13949",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "39",

}

Cimmino, A, Calin, GA, Fabbri, M, Iorio, MV, Ferracin, M, Shimizu, M, Wojcik, SE, Aqeilan, RI, Zupo, S, Dono, M, Rassenti, L, Alder, H, Volinia, S, Liu, CG, Kipps, TJ, Negrini, M & Croce, CM 2005, 'miR-15 and miR-16 induce apoptosis by targeting BCL2', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 39, pp. 13944-13949. https://doi.org/10.1073/pnas.0506654102

TY - JOUR

T1 - miR-15 and miR-16 induce apoptosis by targeting BCL2

AU - Cimmino, Amelia

AU - Calin, George Adrian

AU - Fabbri, Muller

AU - Iorio, Marilena V.

AU - Ferracin, Manuela

AU - Shimizu, Masayoshi

AU - Wojcik, Sylwia E.

AU - Aqeilan, Rami I.

AU - Zupo, Simona

AU - Dono, Mariella

AU - Rassenti, Laura

AU - Alder, Hansjuerg

AU - Volinia, Stefano

AU - Liu, Chang Gong

AU - Kipps, Thomas J.

AU - Negrini, Massimo

AU - Croce, Carlo M.

PY - 2005/9/27

Y1 - 2005/9/27

N2 - Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.

AB - Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.

KW - Leukemia

KW - MicroRNAs

KW - Translation

UR - https://www.scopus.com/pages/publications/25444520537

U2 - 10.1073/pnas.0506654102

DO - 10.1073/pnas.0506654102

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 16166262

AN - SCOPUS:25444520537

SN - 0027-8424

VL - 102

SP - 13944

EP - 13949

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 39

ER -

miR-15 and miR-16 induce apoptosis by targeting BCL2

Abstract

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Keywords

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