TY - JOUR
T1 - Miscibility, interactions and antimicrobial activity of poly(ε-caprolactone)/chloramphenicol blends
AU - Sanchez-Rexach, Eva
AU - Meaurio, Emilio
AU - Iturri, Jagoba
AU - Toca-Herrera, José L.
AU - Nir, Sivan
AU - Reches, Meital
AU - Sarasua, Jose Ramon
N1 - Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/5
Y1 - 2018/5
N2 - Poly(ε-caprolactone) (PCL) has been blended with Chloramphenicol (CAM), a well-known bacteriostatic antibiotic, in order to obtain new biomaterials with antibacterial properties. The resulting samples have been thoroughly characterized regarding both their physicochemical behavior and antimicrobial efficacy by means of very diverse techniques. Hence, PCL/CAM blend miscibility has been analyzed by Differential Scanning Calorimetry (DSC) using the single glass transition temperature (Tg) criterion, intermediate between those corresponding to the two components in the blend. In turn, the interaction parameter has been obtained from the analysis of the melting point depression in both PCL-rich and CAM-rich blends. Fourier-Transform Infra-Red (FTIR) spectroscopy and X-Ray Diffraction (XRD) analysis have been used -in the pure components and in the blends- to analyze both the specific interactions and the crystallization behavior, respectively. The morphology of PCL/CAM blends obtained by spin-coating has been also studied by means of Atomic Force Microscopy (AFM). Finally, drug release kinetics of different PCL/CAM systems as well as their antibacterial efficacy against Escherichia Coli have been investigated, indicating that CAM can be released from the PCL/CAM blends in a controlled way while keeping intact the antibacterial efficiency.
AB - Poly(ε-caprolactone) (PCL) has been blended with Chloramphenicol (CAM), a well-known bacteriostatic antibiotic, in order to obtain new biomaterials with antibacterial properties. The resulting samples have been thoroughly characterized regarding both their physicochemical behavior and antimicrobial efficacy by means of very diverse techniques. Hence, PCL/CAM blend miscibility has been analyzed by Differential Scanning Calorimetry (DSC) using the single glass transition temperature (Tg) criterion, intermediate between those corresponding to the two components in the blend. In turn, the interaction parameter has been obtained from the analysis of the melting point depression in both PCL-rich and CAM-rich blends. Fourier-Transform Infra-Red (FTIR) spectroscopy and X-Ray Diffraction (XRD) analysis have been used -in the pure components and in the blends- to analyze both the specific interactions and the crystallization behavior, respectively. The morphology of PCL/CAM blends obtained by spin-coating has been also studied by means of Atomic Force Microscopy (AFM). Finally, drug release kinetics of different PCL/CAM systems as well as their antibacterial efficacy against Escherichia Coli have been investigated, indicating that CAM can be released from the PCL/CAM blends in a controlled way while keeping intact the antibacterial efficiency.
KW - Antibacterial performance
KW - Chloramphenicol (CAM)
KW - Interactions
KW - Miscibility
KW - Poly(ε-caprolactone) (PCL)
KW - Release kinetics
KW - Spherulitic morphology
UR - http://www.scopus.com/inward/record.url?scp=85043590275&partnerID=8YFLogxK
U2 - 10.1016/j.eurpolymj.2018.03.011
DO - 10.1016/j.eurpolymj.2018.03.011
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AN - SCOPUS:85043590275
SN - 0014-3057
VL - 102
SP - 30
EP - 37
JO - European Polymer Journal
JF - European Polymer Journal
ER -