Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo

Markus J. Tamás; Bruno Fauvet; Philipp Christen; Pierre Goloubinoff

doi:10.1007/s00294-017-0748-x

Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo

Markus J. Tamás^*, Bruno Fauvet, Philipp Christen, Pierre Goloubinoff

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

57 Scopus citations

Abstract

Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.

Original language	English
Pages (from-to)	177-181
Number of pages	5
Journal	Current Genetics
Volume	64
Issue number	1
DOIs	https://doi.org/10.1007/s00294-017-0748-x
State	Published - 1 Feb 2018
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017, The Author(s).

Keywords

Cadmium
Metal toxicity
Molecular chaperones
Protein aggregation
Protein folding
Saccharomyces cerevisiae

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10.1007/s00294-017-0748-x

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abstract = "Cadmium is a highly poisonous metal and a human carcinogen, but the molecular mechanisms underlying its cellular toxicity are not fully understood. Recent findings in yeast cells indicate that cadmium exerts its deleterious effects by inducing widespread misfolding and aggregation of nascent proteins. Here, we discuss this novel mode of toxic heavy metal action and propose a mechanism by which molecular chaperones may reduce the damaging effects of heavy metal ions on protein structures.",

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AU - Goloubinoff, Pierre

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Misfolding and aggregation of nascent proteins: a novel mode of toxic cadmium action in vivo

Abstract

Bibliographical note

Keywords

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