Mitochondrial derived vesicles- Quo Vadis?

Reut Hazan, Ophry Pines, Ann Saada*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Mitochondria are dynamic, intracellular organelles with a separate genome originating from prokaryotes. They perform numerous functions essential for cellular metabolism and energy production. Mitochondrial-derived vesicles (MDVs) are single or double membrane-enclosed vesicles, formed and released from the mitochondrial sub-compartments into the cytosol, in response to various triggers. MDVs interact with other organelles such as lysosomes and peroxisomes or may be incorporated and excreted via extracellular vesicles (EVs). MDVs selectively incorporate diverse protein and lipid cargoes and are involved in various functions such as mitochondrial quality control, immunomodulation, energy complementation, and compartmentalization and transport. This review aims to provide a summary of the current knowledge of MDVs biogenesis, release, cargoes, and roles.

Original languageAmerican English
JournalFEBS Journal
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.


  • membrane
  • mitochondria
  • mitochondrial-derived vesicles


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