We investigated the influence of mode of administration on the pharmacokinetics of a clinically used bisphosphonate, pamidronate, and of suberoylbisphosphonate (SuBP), a novel bisacylphosphonate of the P-CO-(C)n-CO-P type, in rats. Serum drug levels and tissue disposition were determined following administration of the drugs by different modes: intravenous bolus (iso-osmotic and hypo-osmotic solutions), continuous intravenous infusion, and peroral administration. Results of the study indicate that the disposition of the bisphosphonates in soft tissue (liver, kidney and spleen) was dependent on route and rate of drug administration, and on the osmoticity of the vehicle. Consequently, main pharmacokinetic parameters (AUC, CL, and Vss) were influenced by the mode of drug administration, precluding accurate determination of bioavailability from AUC values. On the other hand, bone and urine bisphosphonate accumulation were considerably less dependent on mode of administration, and, therefore, are recommended for bioavailability calculation.
Bibliographical noteFunding Information:
Dr Amnon Hoffman and Professor Gershon Golomb are affiliated with the David R. Bloom Center for Pharmacy. This work is part of D. Stepensky's PhD dissertation. This work was supported in part by the German–Israeli Foundation (GIF) grant No I-383-188.13/94 and by The Israel Science Foundation established by the Israel Academy of Sciences and Humanities.
- Mode of administration dependency
- Nonlinear pharmacokinetics
- Volume of distribution