Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

Yossi Nishri, Nina Fainstein, Smadar Goldfarb, David Hampton, Caterina Macrini, Edgar Meinl, Siddharthan Chandran, Tamir Ben-Hur*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We explored whether experimental autoimmune encephalomyelitis (EAE) in Biozzi mice recapitulates temporal dynamics of tissue injury, immune-pathogenesis and CNS compartmentalization occurring in progressive multiple sclerosis (MS). Chronic EAE exhibited relapsing and progressing disease, partial closure of BBB, reduced tissue inflammatory activity, and development of meningeal ectopic lymphoid tissue, directly opposing (potentially driving) spinal subpial demyelinated plaques. A T cell predominant disease during relapses transformed into a B cell predominant disease in late chronic EAE, with high serum anti-MOG reactivity. Thus, late chronic Biozzi EAE recapitulates essential features of progressive MS, and is suitable for developing disease modifying and regenerative therapies.

Original languageAmerican English
Article number577582
JournalJournal of Neuroimmunology
Volume356
DOIs
StatePublished - 15 Jul 2021

Bibliographical note

Publisher Copyright:
© 2021

Keywords

  • Animal model
  • Demyelination
  • Experimental autoimmune encephalomyelitis
  • Progressive multiple sclerosis

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