Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells: Challenges and Achievements

Carmel Braverman-Gross*, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.

Original languageAmerican English
Article number622940
JournalFrontiers in Endocrinology
Volume12
DOIs
StatePublished - 22 Feb 2021

Bibliographical note

Publisher Copyright:
© Copyright © 2021 Braverman-Gross and Benvenisty.

Keywords

  • disease modeling
  • genetic and epigenetic aberrations
  • human embryonic stem cells
  • induced pluripotent stem cells
  • maturity onset diabetes of the young

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