TY - JOUR
T1 - Modeling Maturity Onset Diabetes of the Young in Pluripotent Stem Cells
T2 - Challenges and Achievements
AU - Braverman-Gross, Carmel
AU - Benvenisty, Nissim
N1 - Publisher Copyright:
© Copyright © 2021 Braverman-Gross and Benvenisty.
PY - 2021/2/22
Y1 - 2021/2/22
N2 - Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.
AB - Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.
KW - disease modeling
KW - genetic and epigenetic aberrations
KW - human embryonic stem cells
KW - induced pluripotent stem cells
KW - maturity onset diabetes of the young
UR - http://www.scopus.com/inward/record.url?scp=85102386625&partnerID=8YFLogxK
U2 - 10.3389/fendo.2021.622940
DO - 10.3389/fendo.2021.622940
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AN - SCOPUS:85102386625
SN - 1664-2392
VL - 12
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
M1 - 622940
ER -
