Abstract
Maturity onset diabetes of the young (MODY), is a group of monogenic diabetes disorders. Rodent models for MODY do not fully recapitulate the human phenotypes, calling for models generated in human cells. Human pluripotent stem cells (hPSCs), capable of differentiation towards pancreatic cells, possess a great opportunity to model MODY disorders in vitro. Here, we review the models for MODY diseases in hPSCs to date and the molecular lessons learnt from them. We also discuss the limitations and challenges that these types of models are still facing.
| Original language | English |
|---|---|
| Article number | 622940 |
| Journal | Frontiers in Endocrinology |
| Volume | 12 |
| DOIs | |
| State | Published - 22 Feb 2021 |
Bibliographical note
Publisher Copyright:© Copyright © 2021 Braverman-Gross and Benvenisty.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- disease modeling
- genetic and epigenetic aberrations
- human embryonic stem cells
- induced pluripotent stem cells
- maturity onset diabetes of the young
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