Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application

Bahaa Shaqour*, Hiba Natsheh, Naim Kittana, Nidal Jaradat, Murad Abualhasan, Ahmad M. Eid, Ruaa Moqady, Aya AbuHijleh, Saja Abu Alsaleem, Shahd Ratrout, Lotte De Wever, Chris Vervaet, Valérie Vanhoorne

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.

Original languageEnglish
Pages (from-to)3833-3841
Number of pages9
JournalACS Biomaterials Science and Engineering
Volume10
Issue number6
DOIs
StatePublished - 10 Jun 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 American Chemical Society.

Keywords

  • 3D printed capsules
  • delayed release
  • fused filament fabrication
  • ketoprofen
  • personalized medicine
  • pH responsive
  • self-nanoemulsifying drug delivery system

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