TY - JOUR
T1 - Modified Release 3D-Printed Capsules Containing a Ketoprofen Self-Nanoemulsifying System for Personalized Medical Application
AU - Shaqour, Bahaa
AU - Natsheh, Hiba
AU - Kittana, Naim
AU - Jaradat, Nidal
AU - Abualhasan, Murad
AU - Eid, Ahmad M.
AU - Moqady, Ruaa
AU - AbuHijleh, Aya
AU - Abu Alsaleem, Saja
AU - Ratrout, Shahd
AU - De Wever, Lotte
AU - Vervaet, Chris
AU - Vanhoorne, Valérie
N1 - Publisher Copyright:
© 2024 American Chemical Society.
PY - 2024/6/10
Y1 - 2024/6/10
N2 - This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.
AB - This study explores the realm of personalized medicine by investigating the utilization of 3D-printed dosage forms, specifically focusing on patient-specific enteric capsules designed for the modified release of ketoprofen, serving as a model drug. The research investigates two distinct scenarios: the modification of drug release from 3D-printed capsules crafted from hydroxypropyl methylcellulose phthalate:polyethylene glycol (HPMCP:PEG) and poly(vinyl alcohol) (PVA), tailored for pH sensitivity and delayed release modes, respectively. Additionally, a novel ketoprofen-loaded self-nanoemulsifying drug delivery system (SNEDDS) based on pomegranate seed oil (PSO) was developed, characterized, and employed as a fill material for the capsules. Through the preparation and characterization of the HPMCP:PEG based filament via the hot-melt extrusion method, the study thoroughly investigated its thermal and mechanical properties. Notably, the in vitro drug release analysis unveiled the intricate interplay between ketoprofen release, polymer type, and capsule thickness. Furthermore, the incorporation of ketoprofen into the SNEDDS exhibited an enhancement in its in vitro cylooxygenase-2 (COX-2) inhibitory activity. These findings collectively underscore the potential of 3D printing in shaping tailored drug delivery systems, thereby contributing significantly to the advancement of personalized medicine.
KW - 3D printed capsules
KW - delayed release
KW - fused filament fabrication
KW - ketoprofen
KW - personalized medicine
KW - pH responsive
KW - self-nanoemulsifying drug delivery system
UR - http://www.scopus.com/inward/record.url?scp=85193536836&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.4c00476
DO - 10.1021/acsbiomaterials.4c00476
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C2 - 38747490
AN - SCOPUS:85193536836
SN - 2373-9878
VL - 10
SP - 3833
EP - 3841
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 6
ER -