Modifying tumor-associated macrophages: An important adjunct to immunotherapy

Zvi G. Fridlender*, Steven M. Albelda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The therapeutic success of immunotherapy requires specific alterations of the tumor microenvironment and/or the inhibition of tumor-elicited immunosuppression. Tumor-associated macrophages (TAMs) are a major component of the tumor microenvironment. We have recently shown that modulating TAMs dramatically augments the efficacy of immunotherapy. TAM-activating agents should hence be considered as an addition to immunotherapy in future clinical trials.

Original languageAmerican English
Article numbere26620
JournalOncoImmunology
Volume2
Issue number12
DOIs
StatePublished - 2013
Externally publishedYes

Keywords

  • DMXAA
  • Immunotherapy
  • Lung cancer
  • Tumor associated macrophages
  • Vaccines

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