Abstract
The profile of liver acyl-CoAs induced by dietary fats of variable compositions or by xenobiotic hypolipidemic amphipathic carboxylates was evaluated in vivo using a novel electrospray ionization tandem mass spectrometry methodology of high resolution, sensitivity, and reliability. The composition of liver fatty acyl-CoAs was found to reflect the composition of dietary fat. Treatment with hypolipidemic carboxylates resulted in liver dominant abundance of their respective acyl-CoAs accompanied by an increase in liver fatty acyl-CoAs. Cellular effects exerted by dietary fatty acids and/or xenobiotic carboxylic drugs may be transduced in vivo by their respective acyl-CoAs.
| Original language | English |
|---|---|
| Pages (from-to) | 1125-1132 |
| Number of pages | 8 |
| Journal | Journal of Lipid Research |
| Volume | 43 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2002 |
Keywords
- Electrospray ionization tandem mass spectrometry
- Fatty acids
- Hepatocyte nuclear factor-4α
- Hypolipidemic drugs
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