Modulation of caveolae by insulin/IGF-1 signaling regulates aging of Caenorhabditis elegans

Noa Roitenberg, Michal Bejerano-Sagie, Hana Boocholez, Lorna Moll, Filipa Carvalhal Marques, Ludmila Golodetzki, Yuval Nevo, Tayir Elami, Ehud Cohen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Reducing insulin/IGF-1 signaling (IIS) extends lifespan, promotes protein homeostasis (proteostasis), and elevates stress resistance of worms, flies, and mammals. How these functions are orchestrated across the organism is only partially understood. Here, we report that in the nematode Caenorhabditis elegans, the IIS positively regulates the expression of caveolin-1 (cav-1), a gene which is primarily expressed in neurons of the adult worm and underlies the formation of caveolae, a subtype of lipid microdomains that serve as platforms for signaling complexes. Accordingly, IIS reduction lowers cav-1 expression and lessens the quantity of neuronal caveolae. Reduced cav-1 expression extends lifespan and mitigates toxic protein aggregation by modulating the expression of aging-regulating and signaling-promoting genes. Our findings define caveolae as aging-governing signaling centers and underscore the potential for cav-1 as a novel therapeutic target for the promotion of healthy aging.

Original languageAmerican English
Article numbere45673
JournalEMBO Reports
Issue number8
StatePublished - Aug 2018

Bibliographical note

Publisher Copyright:
© 2018 The Authors


  • aging
  • caveolae
  • insulin/IGF-1 signaling
  • lifespan
  • proteostasis


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