Modulation of the H‐2 Antigenicity on the Surface of Murine Peritoneal Cells

MICHAEL SCHLESINGER*, MALKA CHAOUAT

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Incubation of peritoneal cells in H‐2 antisera abrogated specifically their sensitivity to the cytotoxic effect of these H‐2 antisera and complement. Incubation of the cells in antisera to either the O‐ or Ly alloantigens did not affect their sensitivity to H‐2 antisera. In F1 hybrid cells, H‐2 antigens determined by one of the parental strains could be modulated by H‐2 antibodies, without affecting the expression of the allelic H‐2 antigens determined by the other parent. Modulation of the H‐2 antigenicity of peritoneal cells resulted from an active metabolic process in the treated cells. The phenomenon was inhibited by exposure of the cells to sodium azide, 2,4 dinitrophenol, iodoacetate, corticosteroid hormones, or colchicine. In contrast, cytosine‐arabinoside, cycloheximide, puromycin, and chloramphenicol had no significant inhibitory effect. It is suggested that modulation of the H‐2 antigenicity of peritoneal cells results from redistribution of the H‐2 antigenicity as a result of pinocytosis.

Original languageEnglish
Pages (from-to)427-435
Number of pages9
JournalTissue Antigens
Volume2
Issue number6
DOIs
StatePublished - Nov 1972

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