Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients

Anat Roitberg-Tambur*, Adam Friedmann, Cilly Safirman, Alice Markitziu, Eldad Ben-Chetrit, Alan Rubinow, Haralampos M. Moutsopoulos, Efthymois Stavropoulos, Fotini N. Skopouli, Hanah Margalit, Chaim Brautbar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


In an attempt to define the role of HLA class II genes in predisposition to primary Sjörgen's syndrome, patients of two different ethnic groups (Israeli Jews and Greeks of non-Jewish origin) suffering from this disorder were studied. Oligonucleotide genotyping revealed the majority in both groups to carry either DRB1 *1101 or DRB1*1104, alleles tha re in linkage disequilibrium with DQB1*0301 and DQA1*0501. The high frequency of the two alleles in these SS patients is in contrast with the accepted association of primary SS with HLA-DR3 in Italian and American individuals. Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501. The fact that the majority of SS patients, across racial and ethnic boundaries, carry a common allele, DQA1*0501, implies its involvement in the predisposition t to primary SS. Based on sequence analysis and the computer imaging of the HLA class II molecule structure, a hypothetical model for the role of the DQ molecule in promoting primary SS us proposed.

Original languageAmerican English
Pages (from-to)235-242
Number of pages8
JournalHuman Immunology
Issue number4
StatePublished - Apr 1993
Externally publishedYes

Bibliographical note

Funding Information:
The authors thank Drs. T. Sasazuki and A. Kimura for providing the HLA oligonucleotide reagents that were used in the 11th International Histocompatibility Workshop. This work was supported in part by grants from the Basic Research Foundation of the Israel Academy of Sciences and Humanities (A.F., C.B.) and the Chief Scientist of the Ministry of Health, Israel (A.M., A.R.T.).


Dive into the research topics of 'Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients'. Together they form a unique fingerprint.

Cite this