Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients

Anat Roitberg-Tambur; Adam Friedmann; Cilly Safirman; Alice Markitziu; Eldad Ben-Chetrit; Alan Rubinow; Haralampos M. Moutsopoulos; Efthymois Stavropoulos; Fotini N. Skopouli; Hanah Margalit; Chaim Brautbar

doi:10.1016/0198-8859(93)90130-S

Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients

Anat Roitberg-Tambur^*, Adam Friedmann, Cilly Safirman, Alice Markitziu, Eldad Ben-Chetrit, Alan Rubinow, Haralampos M. Moutsopoulos, Efthymois Stavropoulos, Fotini N. Skopouli, Hanah Margalit, Chaim Brautbar

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

In an attempt to define the role of HLA class II genes in predisposition to primary Sjörgen's syndrome, patients of two different ethnic groups (Israeli Jews and Greeks of non-Jewish origin) suffering from this disorder were studied. Oligonucleotide genotyping revealed the majority in both groups to carry either DRB1 *1101 or DRB1*1104, alleles tha re in linkage disequilibrium with DQB1*0301 and DQA1*0501. The high frequency of the two alleles in these SS patients is in contrast with the accepted association of primary SS with HLA-DR3 in Italian and American individuals. Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501. The fact that the majority of SS patients, across racial and ethnic boundaries, carry a common allele, DQA1*0501, implies its involvement in the predisposition t to primary SS. Based on sequence analysis and the computer imaging of the HLA class II molecule structure, a hypothetical model for the role of the DQ molecule in promoting primary SS us proposed.

Original language	English
Pages (from-to)	235-242
Number of pages	8
Journal	Human Immunology
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/0198-8859(93)90130-S
State	Published - Apr 1993
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank Drs. T. Sasazuki and A. Kimura for providing the HLA oligonucleotide reagents that were used in the 11th International Histocompatibility Workshop. This work was supported in part by grants from the Basic Research Foundation of the Israel Academy of Sciences and Humanities (A.F., C.B.) and the Chief Scientist of the Ministry of Health, Israel (A.M., A.R.T.).

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Roitberg-Tambur, A., Friedmann, A., Safirman, C., Markitziu, A., Ben-Chetrit, E., Rubinow, A., Moutsopoulos, H. M., Stavropoulos, E., Skopouli, F. N., Margalit, H., & Brautbar, C. (1993). Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients. Human Immunology, 36(4), 235-242. https://doi.org/10.1016/0198-8859(93)90130-S

@article{2d02d4b92b8e47c196ad3f90b91bbccd,

title = "Molecular analysis of HLA class II genes in primary sj{\"o}gren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients",

abstract = "In an attempt to define the role of HLA class II genes in predisposition to primary Sj{\"o}rgen's syndrome, patients of two different ethnic groups (Israeli Jews and Greeks of non-Jewish origin) suffering from this disorder were studied. Oligonucleotide genotyping revealed the majority in both groups to carry either DRB1 *1101 or DRB1*1104, alleles tha re in linkage disequilibrium with DQB1*0301 and DQA1*0501. The high frequency of the two alleles in these SS patients is in contrast with the accepted association of primary SS with HLA-DR3 in Italian and American individuals. Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501. The fact that the majority of SS patients, across racial and ethnic boundaries, carry a common allele, DQA1*0501, implies its involvement in the predisposition t to primary SS. Based on sequence analysis and the computer imaging of the HLA class II molecule structure, a hypothetical model for the role of the DQ molecule in promoting primary SS us proposed.",

author = "Anat Roitberg-Tambur and Adam Friedmann and Cilly Safirman and Alice Markitziu and Eldad Ben-Chetrit and Alan Rubinow and Moutsopoulos, {Haralampos M.} and Efthymois Stavropoulos and Skopouli, {Fotini N.} and Hanah Margalit and Chaim Brautbar",

note = "Funding Information: The authors thank Drs. T. Sasazuki and A. Kimura for providing the HLA oligonucleotide reagents that were used in the 11th International Histocompatibility Workshop. This work was supported in part by grants from the Basic Research Foundation of the Israel Academy of Sciences and Humanities (A.F., C.B.) and the Chief Scientist of the Ministry of Health, Israel (A.M., A.R.T.).",

year = "1993",

month = apr,

doi = "10.1016/0198-8859(93)90130-S",

language = "אנגלית",

volume = "36",

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journal = "Human Immunology",

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Roitberg-Tambur, A, Friedmann, A, Safirman, C, Markitziu, A, Ben-Chetrit, E, Rubinow, A, Moutsopoulos, HM, Stavropoulos, E, Skopouli, FN, Margalit, H & Brautbar, C 1993, 'Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients', Human Immunology, vol. 36, no. 4, pp. 235-242. https://doi.org/10.1016/0198-8859(93)90130-S

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T1 - Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients

AU - Roitberg-Tambur, Anat

AU - Friedmann, Adam

AU - Safirman, Cilly

AU - Markitziu, Alice

AU - Ben-Chetrit, Eldad

AU - Rubinow, Alan

AU - Moutsopoulos, Haralampos M.

AU - Stavropoulos, Efthymois

AU - Skopouli, Fotini N.

AU - Margalit, Hanah

AU - Brautbar, Chaim

N1 - Funding Information: The authors thank Drs. T. Sasazuki and A. Kimura for providing the HLA oligonucleotide reagents that were used in the 11th International Histocompatibility Workshop. This work was supported in part by grants from the Basic Research Foundation of the Israel Academy of Sciences and Humanities (A.F., C.B.) and the Chief Scientist of the Ministry of Health, Israel (A.M., A.R.T.).

PY - 1993/4

Y1 - 1993/4

N2 - In an attempt to define the role of HLA class II genes in predisposition to primary Sjörgen's syndrome, patients of two different ethnic groups (Israeli Jews and Greeks of non-Jewish origin) suffering from this disorder were studied. Oligonucleotide genotyping revealed the majority in both groups to carry either DRB1 *1101 or DRB1*1104, alleles tha re in linkage disequilibrium with DQB1*0301 and DQA1*0501. The high frequency of the two alleles in these SS patients is in contrast with the accepted association of primary SS with HLA-DR3 in Italian and American individuals. Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501. The fact that the majority of SS patients, across racial and ethnic boundaries, carry a common allele, DQA1*0501, implies its involvement in the predisposition t to primary SS. Based on sequence analysis and the computer imaging of the HLA class II molecule structure, a hypothetical model for the role of the DQ molecule in promoting primary SS us proposed.

AB - In an attempt to define the role of HLA class II genes in predisposition to primary Sjörgen's syndrome, patients of two different ethnic groups (Israeli Jews and Greeks of non-Jewish origin) suffering from this disorder were studied. Oligonucleotide genotyping revealed the majority in both groups to carry either DRB1 *1101 or DRB1*1104, alleles tha re in linkage disequilibrium with DQB1*0301 and DQA1*0501. The high frequency of the two alleles in these SS patients is in contrast with the accepted association of primary SS with HLA-DR3 in Italian and American individuals. Molecular analysis of DQB1 and DQA1 alleles found in American Caucasian and American black SS (or SLE) patients demonstrated high frequencies of DQB1*0201 and DQA1*0501. The fact that the majority of SS patients, across racial and ethnic boundaries, carry a common allele, DQA1*0501, implies its involvement in the predisposition t to primary SS. Based on sequence analysis and the computer imaging of the HLA class II molecule structure, a hypothetical model for the role of the DQ molecule in promoting primary SS us proposed.

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JO - Human Immunology

JF - Human Immunology

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ER -

Molecular analysis of HLA class II genes in primary sjögren's syndrome. A study of Israeli Jewish and Greek Non-Jewish patients

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