Molecular characterization of HIV1 nef protein

J. Kaminchik*, N. Sarver, M. Gorecki, A. Panet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.

Original languageEnglish
Pages (from-to)50-52
Number of pages3
JournalResearch in Virology
Volume143
Issue numberC
DOIs
StatePublished - 1992
Externally publishedYes

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