TY - JOUR
T1 - Molecular characterization of HIV1 nef protein
AU - Kaminchik, J.
AU - Sarver, N.
AU - Gorecki, M.
AU - Panet, A.
PY - 1992
Y1 - 1992
N2 - In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.
AB - In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.
UR - http://www.scopus.com/inward/record.url?scp=0026573264&partnerID=8YFLogxK
U2 - 10.1016/S0923-2516(06)80079-8
DO - 10.1016/S0923-2516(06)80079-8
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C2 - 1565857
AN - SCOPUS:0026573264
SN - 0923-2516
VL - 143
SP - 50
EP - 52
JO - Research in Virology
JF - Research in Virology
IS - C
ER -