Molecular characterization of HIV1 nef protein

J. Kaminchik; N. Sarver; M. Gorecki; A. Panet

doi:10.1016/S0923-2516(06)80079-8

Molecular characterization of HIV1 nef protein

J. Kaminchik^*
, N. Sarver
, M. Gorecki
, A. Panet

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.

Original language	English
Pages (from-to)	50-52
Number of pages	3
Journal	Research in Virology
Volume	143
Issue number	C
DOIs	https://doi.org/10.1016/S0923-2516(06)80079-8
State	Published - 1992
Externally published	Yes

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title = "Molecular characterization of HIV1 nef protein",

abstract = "In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.",

author = "J. Kaminchik and N. Sarver and M. Gorecki and A. Panet",

year = "1992",

doi = "10.1016/S0923-2516(06)80079-8",

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journal = "Research in Virology",

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AU - Kaminchik, J.

AU - Sarver, N.

AU - Gorecki, M.

AU - Panet, A.

PY - 1992

Y1 - 1992

N2 - In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.

AB - In summary, data presented here demonstrate that nef codes for two proteins, Nef-p27 and Nef-p25, by a mechanism of alternative transnational initiation. Nef-p27 is a myristoylated protein, partially associated with various components of the cytoplasmic particulate fraction. Nef-p25 is a soluble monomeric protein found exclusively in the cytosol. The association of Nef-p27 with the cytoskeletal infrastructure maybe relatd to its biological role in vivo, an area under intense investigation. No G-protein-like activity was detected in purified recombinant Nef coded by nef genes of three different HIV1 isolates.

UR - https://www.scopus.com/pages/publications/0026573264

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JO - Research in Virology

JF - Research in Virology

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Molecular characterization of HIV1 nef protein

Abstract

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