Molecular characterization of the Aedes aegypti odorant receptor gene family

J. Bohbot, R. J. Pitts, H. W. Kwon, M. Rützler, H. M. Robertson, L. J. Zwiebel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

180 Scopus citations


The olfactory-driven blood-feeding behaviour of female Aedes aegypti mosquitoes is the primary transmission mechanism by which the arboviruses causing dengue and yellow fevers affect over 40 million individuals worldwide. Bioinformatics analysis has been used to identify 131 putative odourant receptors from the A. aegypti genome that are likely to function in chemosensory perception in this mosquito. Comparison with the Anopheles gambiae olfactory subgenome demonstrates significant divergence of the odourant receptors that reflects a high degree of evolutionary activity potentially resulting from their critical roles during the mosquito life cycle. Expression analyses in the larval and adult olfactory chemosensory organs reveal that the ratio of odourant receptors to antennal glomeruli is not necessarily one to one in mosquitoes.

Original languageAmerican English
Pages (from-to)525-537
Number of pages13
JournalInsect Molecular Biology
Issue number5
StatePublished - Oct 2007
Externally publishedYes


  • Aedes aegypti
  • Anopheles gambiae
  • Genome
  • Odourant receptor
  • Olfaction


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