TY - JOUR
T1 - Molecular cloning of the zeta chain of the T cell antigen receptor
AU - Weissman, Allan M.
AU - Baniyash, Michal
AU - Hou, Damon
AU - Samelson, Lawrence E.
AU - Burgess, Wilson H.
AU - Klausner, Richard D.
PY - 1988
Y1 - 1988
N2 - The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.
AB - The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.
UR - http://www.scopus.com/inward/record.url?scp=0023907648&partnerID=8YFLogxK
U2 - 10.1126/science.3278377
DO - 10.1126/science.3278377
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C2 - 3278377
AN - SCOPUS:0023907648
SN - 0036-8075
VL - 239
SP - 1018
EP - 1021
JO - Science
JF - Science
IS - 4843
ER -