Molecular cloning of the zeta chain of the T cell antigen receptor

Allan M. Weissman*, Michal Baniyash, Damon Hou, Lawrence E. Samelson, Wilson H. Burgess, Richard D. Klausner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

265 Scopus citations


The T cell antigen receptor is a multi-subunit receptor complex present on the surface of all mature and many developing T cells. It consists of clonotypic heterodimers noncovalently linked to five invariant chains that are encoded by four genes and referred to as the CD3 complex. The CD3 gamma, delta, and epsilon chains have been molecularly characterized. In this report the molecular cloning of a complementary DNA encoding the zeta chain of the murine T cell antigen receptor is described. The predicted protein sequence of the zeta chain suggests a structure distinct from those of any of the previously described receptor subunits.

Original languageAmerican English
Pages (from-to)1018-1021
Number of pages4
Issue number4843
StatePublished - 1988
Externally publishedYes


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