TY - JOUR
T1 - Molecular determinants of substrate specificity in sodium-coupled glutamate transporters
AU - Silverstein, Nechama
AU - Ewers, David
AU - Forrest, Lucy R.
AU - Fahlke, Christoph
AU - Kanner, Baruch I.
PY - 2015/11/27
Y1 - 2015/11/27
N2 - Background: Archaeal and brain transporters differ in substrate specificity. Results: Two residues from hairpin 2 play a role in the substrate specificity of a glutamate transporter homologue. Conclusion: Hairpin 2 plays a role in the selection and translocation of the substrate. Significance: This work provides new insights into the molecular basis of substrate specificity of transporters.
AB - Background: Archaeal and brain transporters differ in substrate specificity. Results: Two residues from hairpin 2 play a role in the substrate specificity of a glutamate transporter homologue. Conclusion: Hairpin 2 plays a role in the selection and translocation of the substrate. Significance: This work provides new insights into the molecular basis of substrate specificity of transporters.
UR - http://www.scopus.com/inward/record.url?scp=84948456629&partnerID=8YFLogxK
U2 - 10.1074/jbc.M115.682666
DO - 10.1074/jbc.M115.682666
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C2 - 26475859
AN - SCOPUS:84948456629
SN - 0021-9258
VL - 290
SP - 28988
EP - 28996
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 48
ER -