Molecular determinants of substrate specificity in sodium-coupled glutamate transporters

Nechama Silverstein; David Ewers; Lucy R. Forrest; Christoph Fahlke; Baruch I. Kanner

doi:10.1074/jbc.M115.682666

Molecular determinants of substrate specificity in sodium-coupled glutamate transporters

Nechama Silverstein
, David Ewers
, Lucy R. Forrest
, Christoph Fahlke
, Baruch I. Kanner^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Archaeal and brain transporters differ in substrate specificity. Results: Two residues from hairpin 2 play a role in the substrate specificity of a glutamate transporter homologue. Conclusion: Hairpin 2 plays a role in the selection and translocation of the substrate. Significance: This work provides new insights into the molecular basis of substrate specificity of transporters.

Original language	English
Pages (from-to)	28988-28996
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	290
Issue number	48
DOIs	https://doi.org/10.1074/jbc.M115.682666
State	Published - 27 Nov 2015

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AU - Kanner, Baruch I.

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AB - Background: Archaeal and brain transporters differ in substrate specificity. Results: Two residues from hairpin 2 play a role in the substrate specificity of a glutamate transporter homologue. Conclusion: Hairpin 2 plays a role in the selection and translocation of the substrate. Significance: This work provides new insights into the molecular basis of substrate specificity of transporters.

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Molecular determinants of substrate specificity in sodium-coupled glutamate transporters

Abstract

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