Abstract
The entry of substrate into the active site is the first event in any enzymatic reaction. However, due to the short time interval between the encounter and the formation of the stable complex, the detailed steps are experimentally unobserved. In the present study, we report a molecular dynamics simulation of the encounter between palmitate molecule and the Toad Liver fatty acid binding protein, ending with the formation of a stable complex resemblance in structure of other proteins of this family. The forces operating on the system leading to the formation of the tight complex are discussed.
Original language | English |
---|---|
Pages (from-to) | 1243-1247 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 581 |
Issue number | 6 |
DOIs | |
State | Published - 20 Mar 2007 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by the United States–Israel Binational Science Foundation (2002129). R.F. greatly acknowledges the Colton Foundation for supporting him through the Colton Fellowship.
Keywords
- Fatty acid binding proteins
- Molecular dynamics
- Molecular modeling
- Palmitic acid