Molecular events in the processing of avidin by antigen-presenting cells (APC) - III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products

Aharon Friedman; Rachel Zerubavel; Carlos Gitler; Irun R. Cohen

doi:10.1007/BF00952967

Molecular events in the processing of avidin by antigen-presenting cells (APC) - III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products

Aharon Friedman^*, Rachel Zerubavel, Carlos Gitler, Irun R. Cohen

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

We investigated the interaction between processed avidin (PA) and avidin-specific lines of T lymphocytes free of resident antigen-presenting cells (APC). We found that PA was able to replace the requirement for APC in the T-lymphocyte proliferative assay, only if the PA was associated with an Ia-positive moiety (IPM) supplied by the APC. In addition to supplying a necessary signal for a proliferative response to PA, IPM imposed H-2 restriction on the PA molecule. The association between PA and IPM was reversible and the two moieties could be physically separated and recombined. The results support a conclusion that major histocompatibility restriction of the interaction between T lymphocytes and APC is due to the association between processed antigen and an APC element containing I-region products.

Original language	English
Pages (from-to)	291-302
Number of pages	12
Journal	Immunogenetics
Volume	18
Issue number	3
DOIs	https://doi.org/10.1007/BF00952967
State	Published - May 1983
Externally published	Yes

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title = "Molecular events in the processing of avidin by antigen-presenting cells (APC) - III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products",

abstract = "We investigated the interaction between processed avidin (PA) and avidin-specific lines of T lymphocytes free of resident antigen-presenting cells (APC). We found that PA was able to replace the requirement for APC in the T-lymphocyte proliferative assay, only if the PA was associated with an Ia-positive moiety (IPM) supplied by the APC. In addition to supplying a necessary signal for a proliferative response to PA, IPM imposed H-2 restriction on the PA molecule. The association between PA and IPM was reversible and the two moieties could be physically separated and recombined. The results support a conclusion that major histocompatibility restriction of the interaction between T lymphocytes and APC is due to the association between processed antigen and an APC element containing I-region products.",

author = "Aharon Friedman and Rachel Zerubavel and Carlos Gitler and Cohen, {Irun R.}",

year = "1983",

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Molecular events in the processing of avidin by antigen-presenting cells (APC) - III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products. / Friedman, Aharon; Zerubavel, Rachel; Gitler, Carlos et al.
In: Immunogenetics, Vol. 18, No. 3, 05.1983, p. 291-302.

Research output: Contribution to journal › Article › peer-review

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AU - Cohen, Irun R.

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AB - We investigated the interaction between processed avidin (PA) and avidin-specific lines of T lymphocytes free of resident antigen-presenting cells (APC). We found that PA was able to replace the requirement for APC in the T-lymphocyte proliferative assay, only if the PA was associated with an Ia-positive moiety (IPM) supplied by the APC. In addition to supplying a necessary signal for a proliferative response to PA, IPM imposed H-2 restriction on the PA molecule. The association between PA and IPM was reversible and the two moieties could be physically separated and recombined. The results support a conclusion that major histocompatibility restriction of the interaction between T lymphocytes and APC is due to the association between processed antigen and an APC element containing I-region products.

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Molecular events in the processing of avidin by antigen-presenting cells (APC) - III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products

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