Molecular imaging of membrane drug efflux transporters activity in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter


Molecular imaging involves minimally-invasive quantitative measurement of biological processes in vivo, complementing biosample-based analyses. Molecular imaging can provide unique insight into disease processes and guide precision oncology, ranging from improved diagnosis to monitoring treatment response. This chapter presents the application of molecular imaging in the study of drug efflux transporters. It introduces established and emerging imaging technologies and probes used in monitoring and predicting efflux transporter-mediated processes. The focus is on imaging of transporters expressed in tumor cells. However, also described are potential uses of molecular imaging in understanding and quantifying the role of extra-tumoral transporters in the efficacy and safety of cancer therapies.
Original languageAmerican English
Title of host publicationDrug Efflux Pumps in Cancer Resistance Pathways:
Subtitle of host publicationFrom Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
EditorsAlejandro Sosnik, Reina Bendayan
PublisherAcademic Press
Number of pages24
ISBN (Print)978-0-12-816434-1
StatePublished - 2020


  • Drug transporters
  • Multidrug resistance
  • Molecular imaging
  • Positron emission tomography
  • Single-photon emission computerized tomography
  • Magnetic resonance imaging
  • Optical imaging
  • P-glycoprotein
  • Breast cancer resistance protein
  • Multidrug resistance proteins


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