Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

Aniv Mann, Inessa Semenenko, Michal Meir, Sara Eyal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.

Original languageAmerican English
Pages (from-to)788-801
Number of pages14
JournalAAPS Journal
Volume17
Issue number4
DOIs
StatePublished - 24 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015, American Association of Pharmaceutical Scientists.

Keywords

  • membrane transporters
  • molecular imaging
  • multidrug resistance
  • near infrared
  • optical imaging

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