Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

Aniv Mann; Inessa Semenenko; Michal Meir; Sara Eyal

doi:10.1208/s12248-015-9752-6

Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

Aniv Mann, Inessa Semenenko, Michal Meir, Sara Eyal^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.

Original language	English
Pages (from-to)	788-801
Number of pages	14
Journal	AAPS Journal
Volume	17
Issue number	4
DOIs	https://doi.org/10.1208/s12248-015-9752-6
State	Published - 24 Jul 2015

Bibliographical note

Publisher Copyright:
© 2015, American Association of Pharmaceutical Scientists.

Keywords

membrane transporters
molecular imaging
multidrug resistance
near infrared
optical imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1208/s12248-015-9752-6

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Molecular Imaging of Membrane Transporters’ Activity in Cancer: a Picture is Worth a Thousand Tubes

Abstract

Bibliographical note

Keywords

UN SDGs

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