Abstract
Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 788-801 |
| Number of pages | 14 |
| Journal | AAPS Journal |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - 24 Jul 2015 |
Bibliographical note
Publisher Copyright:© 2015, American Association of Pharmaceutical Scientists.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- membrane transporters
- molecular imaging
- multidrug resistance
- near infrared
- optical imaging
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