Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans

Jinchuan Hu, Christopher P. Selby, Sheera Adar, Ogun Adebali, Aziz Sancar*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

61 Scopus citations

Abstract

Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.

Original languageAmerican English
Pages (from-to)15588-15597
Number of pages10
JournalJournal of Biological Chemistry
Volume292
Issue number38
DOIs
StatePublished - 22 Sep 2017

Bibliographical note

Publisher Copyright:
© 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

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