Molecular profiling of breast cancer: Portraits but not physiognomy

James D. Brenton; A. J.R.Samuel Aparicio; Carlos Caldas

doi:10.1186/bcr274

Molecular profiling of breast cancer: Portraits but not physiognomy

James D. Brenton^*
, A. J.R.Samuel Aparicio
, Carlos Caldas

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative 'breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.

Original language	English
Pages (from-to)	77-80
Number of pages	4
Journal	Breast Cancer Research
Volume	3
Issue number	2
DOIs	https://doi.org/10.1186/bcr274
State	Published - 2001
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Hierarchical clustering
Molecular profiling
cDNA microarray

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10.1186/bcr274

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abstract = "Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative 'breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.",

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AB - Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative 'breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.

KW - Breast cancer

KW - Hierarchical clustering

KW - Molecular profiling

KW - cDNA microarray

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ER -

Molecular profiling of breast cancer: Portraits but not physiognomy

Abstract

UN SDGs

Keywords

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