Abstract
Metallic nanoparticles (NPs) exhibiting unique electrical [1-3], optical [4], and catalytic [5] functions find growing interest for sensor applications [6], for the fabrication of nanoscale devices, such as field effect transistors [7], and as new catalysts for different chemical transformations [8]. The electrical, catalytic, and optical properties of metallic NPs were extensively used to develop optical and catalytic labels for recognition events and were implemented as nano-elements for the assembly of specific sensors. For example, metallic (Pt) NPs acted as electrocatalysts for the amplified amperometric detection of DNA or aptamer-substrate complexes, through the electrocatalytic reduction of H2O2 [9]. The interparticle coupling of the localized plasmon of the NPs was found to generate a lower energy excitation transition, leading to a red-to-blue color change upon the aggregation of individual Au NPs into aggregated composites. This optical feature was widely used to develop numerous biosensors (e.g., DNA, aptamer-substrate, or antigen-antibody complexes) [10,11], or ion-sensors [12]. Similarly, molecular receptors were used to link together layered porous assemblies of Au NPs. The receptors provided specific recognition sites for the respective analytes (e.g., adrenaline) [13], whereas the three-dimensional conductivity of the Au NPs enabled the electrical detection of the analytes that were associated to the receptor units in the composite [14].
Original language | English |
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Title of host publication | Handbook of Molecular Imprinting |
Subtitle of host publication | Advanced Sensor Applications |
Publisher | Pan Stanford Publishing Pte. Ltd. |
Pages | 453-485 |
Number of pages | 33 |
ISBN (Electronic) | 9789814364324 |
ISBN (Print) | 9789814316651 |
State | Published - 1 Jan 2012 |
Bibliographical note
Publisher Copyright:© 2013 Pan Stanford Publishing Pte. Ltd.