Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Shlomit Guy; Dvir Rotem; Zvi Hayouka; Ronen Gabizon; Aviad Levin; Limor Zemel; Abraham Loyter; Danny Porath; Assaf Friedler

doi:10.1039/c3cc40748a

Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Shlomit Guy
, Dvir Rotem
, Zvi Hayouka
, Ronen Gabizon
, Aviad Levin
, Limor Zemel
, Abraham Loyter
, Danny Porath
, Assaf Friedler^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

Original language	English
Pages (from-to)	3113-3115
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	30
DOIs	https://doi.org/10.1039/c3cc40748a
State	Published - 19 Mar 2013

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10.1039/c3cc40748a

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abstract = "Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.",

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AU - Guy, Shlomit

AU - Rotem, Dvir

AU - Hayouka, Zvi

AU - Gabizon, Ronen

AU - Levin, Aviad

AU - Zemel, Limor

AU - Loyter, Abraham

AU - Porath, Danny

AU - Friedler, Assaf

PY - 2013/3/19

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N2 - Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

AB - Integration of the HIV cDNA into the host chromosome is a key event in the viral replication cycle. It is mediated by the viral integrase (IN) enzyme, which is an attractive anti-HIV drug target. Here we present the first AFM imaging of IN-mediated DNA integration products in a two-LTR system.

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Monitoring the HIV-1 integrase enzymatic activity using atomic force microscopy in a 2LTR system

Abstract

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