TY - JOUR
T1 - Monoclonal antibodies to immunogenic lymphoma cell variants displaying impaired neoplastic properties
T2 - Characterization and applications
AU - Hochman, Jacob
AU - Park, Sang S.
AU - Lazarovici, Philip
AU - Bergel, Michael
AU - Gottesman, Michael M.
PY - 1990/12/5
Y1 - 1990/12/5
N2 - Immunogenic, nontumorigenic cell variants derived from the highly tumorigenic mouse lymphoma cell line S-49 were used to raise monoclonal antibodies (MAbs) in syngeneic BALB/c mice. MAbs of the following specifications were derived: (a) MAbs that interacted perferentially with the immunogenic variants, (b) MAbs that interacted with both immunogenic variants and parental tumorigenic cells, and (c) a MAb that interacted with both immunogenic and tumorigenic S-49 cells and the normal BALB/c splenocytes. Six MAbs raised in this way were found to recognize at least five different cell-surface epitopes. Functional analysis of the different MAbs suggested their potential usefulness in passive immunization against parental tumorigenic cells as well as in enrichment of immunogenic cells from a mixed population containing a preponderance of tumorigenic cells. [J Natl Cancer Inst 82:1821-1826, 1990]
AB - Immunogenic, nontumorigenic cell variants derived from the highly tumorigenic mouse lymphoma cell line S-49 were used to raise monoclonal antibodies (MAbs) in syngeneic BALB/c mice. MAbs of the following specifications were derived: (a) MAbs that interacted perferentially with the immunogenic variants, (b) MAbs that interacted with both immunogenic variants and parental tumorigenic cells, and (c) a MAb that interacted with both immunogenic and tumorigenic S-49 cells and the normal BALB/c splenocytes. Six MAbs raised in this way were found to recognize at least five different cell-surface epitopes. Functional analysis of the different MAbs suggested their potential usefulness in passive immunization against parental tumorigenic cells as well as in enrichment of immunogenic cells from a mixed population containing a preponderance of tumorigenic cells. [J Natl Cancer Inst 82:1821-1826, 1990]
UR - http://www.scopus.com/inward/record.url?scp=0025683115&partnerID=8YFLogxK
U2 - 10.1093/jnci/82.23.1821
DO - 10.1093/jnci/82.23.1821
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C2 - 2250297
AN - SCOPUS:0025683115
SN - 0027-8874
VL - 82
SP - 1821
EP - 1826
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 23
ER -
