Monomers and polymers of Δ¹(6) tetrahydrocannabinol and cannabidiol

The O methacryloyl derivatives of Δ¹(⁶) THC and of cannabidiol (mono and di) were synthesized and subjected to free radical polymerization. The parent compounds were linked to the terminal carbons of polyethylene oxide (PEO) of different ml wt by a carbonate bond, after transforming the terminal hydroxyl of PEO into their chlorocarbonate derivatives. The hydroxyl groups of Δ¹(⁶) THC and cannabidiol were converted to the corresponding chlorocarbonate derivatives which were utilized for the synthesis of a carbonate dimer of Δ¹(⁶) THC and of a polycarbonate of cannabidiol, respectively, as well as for the synthesis of carbamate derivatives with amines and amino acids. The psychothomimetic activity of the Δ¹(⁶) THC compounds was tested, and some of them showed similar activity to the original Δ¹(⁶) THC.