Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma x glioma hybrid cells

Uriel Bachrach; Dona Benalal; Avinoam Reches

doi:10.1016/0024-3205(79)90608-8

Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma x glioma hybrid cells

Uriel Bachrach^*, Dona Benalal, Avinoam Reches

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of morphine on neuroblastoma x glioma hybrid cells is not limited to the inhibition of adenylate cyclase activity. It is demonstrated that in morphine-treated cells there is a marked reduction in the activity of both cyclic AMP-dependent protein kinase and ornithine decarboxylase (ODC) in response to stimulation by PGE₁. The effect of morphine is to block a cascade of events which may be crucial for the normal biochemical processes in these cells.

Original language	English
Pages (from-to)	1879-1883
Number of pages	5
Journal	Life Sciences
Volume	25
Issue number	22
DOIs	https://doi.org/10.1016/0024-3205(79)90608-8
State	Published - 26 Nov 1979

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10.1016/0024-3205(79)90608-8

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abstract = "The effect of morphine on neuroblastoma x glioma hybrid cells is not limited to the inhibition of adenylate cyclase activity. It is demonstrated that in morphine-treated cells there is a marked reduction in the activity of both cyclic AMP-dependent protein kinase and ornithine decarboxylase (ODC) in response to stimulation by PGE1. The effect of morphine is to block a cascade of events which may be crucial for the normal biochemical processes in these cells.",

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N2 - The effect of morphine on neuroblastoma x glioma hybrid cells is not limited to the inhibition of adenylate cyclase activity. It is demonstrated that in morphine-treated cells there is a marked reduction in the activity of both cyclic AMP-dependent protein kinase and ornithine decarboxylase (ODC) in response to stimulation by PGE1. The effect of morphine is to block a cascade of events which may be crucial for the normal biochemical processes in these cells.

AB - The effect of morphine on neuroblastoma x glioma hybrid cells is not limited to the inhibition of adenylate cyclase activity. It is demonstrated that in morphine-treated cells there is a marked reduction in the activity of both cyclic AMP-dependent protein kinase and ornithine decarboxylase (ODC) in response to stimulation by PGE1. The effect of morphine is to block a cascade of events which may be crucial for the normal biochemical processes in these cells.

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Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma x glioma hybrid cells

Abstract

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