Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake

Israel Lieblich; Edna Cohen; Judith R. Ganchrow; Elliott M. Blass; Felix Bergmann

doi:10.1126/science.6879185

Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake

Israel Lieblich
, Edna Cohen
, Judith R. Ganchrow
, Elliott M. Blass^*
, Felix Bergmann

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.

Original language	English
Pages (from-to)	871-873
Number of pages	3
Journal	Science
Volume	221
Issue number	4613
DOIs	https://doi.org/10.1126/science.6879185
State	Published - 1983

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title = "Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake",

abstract = "Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.",

author = "Israel Lieblich and Edna Cohen and Ganchrow, \{Judith R.\} and Blass, \{Elliott M.\} and Felix Bergmann",

year = "1983",

doi = "10.1126/science.6879185",

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journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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T1 - Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake

AU - Lieblich, Israel

AU - Cohen, Edna

AU - Ganchrow, Judith R.

AU - Blass, Elliott M.

AU - Bergmann, Felix

PY - 1983

Y1 - 1983

N2 - Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.

AB - Rats of line LC2-Hi that drank about 50 milliliters of a highly palatable saccharine solution daily for 28 consecutive days did not show morphine analgesia or an opioid form of stress-induced analgesia and were not responsive to naloxone. These findings support the idea that chronically elevated saccharine intake may cause increased release and utilization of endogenous opiates.

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AN - SCOPUS:0020576118

SN - 0036-8075

VL - 221

SP - 871

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JO - Science

JF - Science

IS - 4613

ER -

Morphine tolerance in genetically selected rats induced by chronically elevated saccharine intake

Abstract

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