Morphometrical study of minor salivary gland in xerostomic patients with altered lipid metabolism

L. Lukach, A. Maly, A. Zini, D. J. Aframian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: To evaluate the correlation between dyslipidemia in patients with oral dryness and the development of non-specific histopathological findings in their labial salivary gland biopsies. Methods: Thirty seven patients suffering from oral dryness (18 patients with dyslipidemia and 19 age-matched patients with normal lipid blood levels) underwent labial salivary gland biopsy. Total acinar area (TAA), acinar cell number, acinar lumen area (ALA), duct lumen area (DLA), area occupied by cells in acinus (AoCA), and area of one acinar cell (OAC) were calculated. Results: A significantly (P < 0.05) increased AoCA, OAC, and DLA in labial glands from patients with impaired lipid metabolism, compared to controls, were found. Conclusion: A positive relationship between dyslipidemia and morphological changes in labial salivary glands was obtained.

Original languageAmerican English
Pages (from-to)714-719
Number of pages6
JournalOral Diseases
Issue number7
StatePublished - 1 Oct 2014

Bibliographical note

Publisher Copyright:
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


  • Dyslipidemia
  • Labial salivary glands
  • Oral dryness
  • Sjogren's syndrome
  • Xerostomia


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