Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Pamela Ferretti; Edoardo Pasolli; Adrian Tett; Francesco Asnicar; Valentina Gorfer; Sabina Fedi; Federica Armanini; Duy Tin Truong; Serena Manara; Moreno Zolfo; Francesco Beghini; Roberto Bertorelli; Veronica De Sanctis; Ilaria Bariletti; Rosarita Canto; Rosanna Clementi; Marina Cologna; Tiziana Crifò; Giuseppina Cusumano; Stefania Gottardi; Claudia Innamorati; Caterina Masè; Daniela Postai; Daniela Savoi; Sabrina Duranti; Gabriele Andrea Lugli; Leonardo Mancabelli; Francesca Turroni; Chiara Ferrario; Christian Milani; Marta Mangifesta; Rosaria Anzalone; Alice Viappiani; Moran Yassour; Hera Vlamakis; Ramnik Xavier; Carmen Maria Collado; Omry Koren; Saverio Tateo; Massimo Soffiati; Anna Pedrotti; Marco Ventura; Curtis Huttenhower; Peer Bork; Nicola Segata

doi:10.1016/j.chom.2018.06.005

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Pamela Ferretti, Edoardo Pasolli, Adrian Tett, Francesco Asnicar, Valentina Gorfer, Sabina Fedi, Federica Armanini, Duy Tin Truong, Serena Manara, Moreno Zolfo, Francesco Beghini, Roberto Bertorelli, Veronica De Sanctis, Ilaria Bariletti, Rosarita Canto, Rosanna Clementi, Marina Cologna, Tiziana Crifò, Giuseppina Cusumano, Stefania GottardiClaudia Innamorati, Caterina Masè, Daniela Postai, Daniela Savoi, Sabrina Duranti, Gabriele Andrea Lugli, Leonardo Mancabelli, Francesca Turroni, Chiara Ferrario, Christian Milani, Marta Mangifesta, Rosaria Anzalone, Alice Viappiani, Moran Yassour, Hera Vlamakis, Ramnik Xavier, Carmen Maria Collado, Omry Koren, Saverio Tateo, Massimo Soffiati, Anna Pedrotti, Marco Ventura, Curtis Huttenhower, Peer Bork, Nicola Segata^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

791 Scopus citations

Abstract

Ferretti et al. use metagenomics with strain-resolved computational profiling to characterize the transfer of microbes from mothers to their infants during their first 4 months of life. Multiple maternal body sites contribute to the developing infant microbiome, with maternal gut strains providing the largest contribution of colonizing microorganisms.

Original language	English
Pages (from-to)	133-145.e5
Journal	Cell Host and Microbe
Volume	24
Issue number	1
DOIs	https://doi.org/10.1016/j.chom.2018.06.005
State	Published - 11 Jul 2018
Externally published	Yes

Bibliographical note

Funding Information:
We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG- 716575 ), MIUR “Futuro in Ricerca” RBFR13EWWI_001 , the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant ( 707345 ) to E.P.

Funding Information:
We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG-716575), MIUR “Futuro in Ricerca” RBFR13EWWI_001, the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant (707345) to E.P.

Keywords

infant microbiome
microbiome transmission
shotgun metagenomics
strain-level profiling

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10.1016/j.chom.2018.06.005

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Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Gorfer, V., Fedi, S., Armanini, F., Truong, D. T., Manara, S., Zolfo, M., Beghini, F., Bertorelli, R., De Sanctis, V., Bariletti, I., Canto, R., Clementi, R., Cologna, M., Crifò, T., Cusumano, G., ... Segata, N. (2018). Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome. Cell Host and Microbe, 24(1), 133-145.e5. https://doi.org/10.1016/j.chom.2018.06.005

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title = "Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome",

abstract = "Ferretti et al. use metagenomics with strain-resolved computational profiling to characterize the transfer of microbes from mothers to their infants during their first 4 months of life. Multiple maternal body sites contribute to the developing infant microbiome, with maternal gut strains providing the largest contribution of colonizing microorganisms.",

keywords = "infant microbiome, microbiome transmission, shotgun metagenomics, strain-level profiling",

author = "Pamela Ferretti and Edoardo Pasolli and Adrian Tett and Francesco Asnicar and Valentina Gorfer and Sabina Fedi and Federica Armanini and Truong, {Duy Tin} and Serena Manara and Moreno Zolfo and Francesco Beghini and Roberto Bertorelli and {De Sanctis}, Veronica and Ilaria Bariletti and Rosarita Canto and Rosanna Clementi and Marina Cologna and Tiziana Crif{\`o} and Giuseppina Cusumano and Stefania Gottardi and Claudia Innamorati and Caterina Mas{\`e} and Daniela Postai and Daniela Savoi and Sabrina Duranti and Lugli, {Gabriele Andrea} and Leonardo Mancabelli and Francesca Turroni and Chiara Ferrario and Christian Milani and Marta Mangifesta and Rosaria Anzalone and Alice Viappiani and Moran Yassour and Hera Vlamakis and Ramnik Xavier and Collado, {Carmen Maria} and Omry Koren and Saverio Tateo and Massimo Soffiati and Anna Pedrotti and Marco Ventura and Curtis Huttenhower and Peer Bork and Nicola Segata",

note = "Funding Information: We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG- 716575 ), MIUR “Futuro in Ricerca” RBFR13EWWI_001 , the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant ( 707345 ) to E.P. Funding Information: We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG-716575), MIUR “Futuro in Ricerca” RBFR13EWWI_001, the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant (707345) to E.P.",

year = "2018",

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day = "11",

doi = "10.1016/j.chom.2018.06.005",

language = "אנגלית",

volume = "24",

pages = "133--145.e5",

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Ferretti, P, Pasolli, E, Tett, A, Asnicar, F, Gorfer, V, Fedi, S, Armanini, F, Truong, DT, Manara, S, Zolfo, M, Beghini, F, Bertorelli, R, De Sanctis, V, Bariletti, I, Canto, R, Clementi, R, Cologna, M, Crifò, T, Cusumano, G, Gottardi, S, Innamorati, C, Masè, C, Postai, D, Savoi, D, Duranti, S, Lugli, GA, Mancabelli, L, Turroni, F, Ferrario, C, Milani, C, Mangifesta, M, Anzalone, R, Viappiani, A, Yassour, M, Vlamakis, H, Xavier, R, Collado, CM, Koren, O, Tateo, S, Soffiati, M, Pedrotti, A, Ventura, M, Huttenhower, C, Bork, P & Segata, N 2018, 'Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome', Cell Host and Microbe, vol. 24, no. 1, pp. 133-145.e5. https://doi.org/10.1016/j.chom.2018.06.005

TY - JOUR

T1 - Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

AU - Ferretti, Pamela

AU - Pasolli, Edoardo

AU - Tett, Adrian

AU - Asnicar, Francesco

AU - Gorfer, Valentina

AU - Fedi, Sabina

AU - Armanini, Federica

AU - Truong, Duy Tin

AU - Manara, Serena

AU - Zolfo, Moreno

AU - Beghini, Francesco

AU - Bertorelli, Roberto

AU - De Sanctis, Veronica

AU - Bariletti, Ilaria

AU - Canto, Rosarita

AU - Clementi, Rosanna

AU - Cologna, Marina

AU - Crifò, Tiziana

AU - Cusumano, Giuseppina

AU - Gottardi, Stefania

AU - Innamorati, Claudia

AU - Masè, Caterina

AU - Postai, Daniela

AU - Savoi, Daniela

AU - Duranti, Sabrina

AU - Lugli, Gabriele Andrea

AU - Mancabelli, Leonardo

AU - Turroni, Francesca

AU - Ferrario, Chiara

AU - Milani, Christian

AU - Mangifesta, Marta

AU - Anzalone, Rosaria

AU - Viappiani, Alice

AU - Yassour, Moran

AU - Vlamakis, Hera

AU - Xavier, Ramnik

AU - Collado, Carmen Maria

AU - Koren, Omry

AU - Tateo, Saverio

AU - Soffiati, Massimo

AU - Pedrotti, Anna

AU - Ventura, Marco

AU - Huttenhower, Curtis

AU - Bork, Peer

AU - Segata, Nicola

N1 - Funding Information: We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG- 716575 ), MIUR “Futuro in Ricerca” RBFR13EWWI_001 , the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant ( 707345 ) to E.P. Funding Information: We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG-716575), MIUR “Futuro in Ricerca” RBFR13EWWI_001, the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant (707345) to E.P.

PY - 2018/7/11

Y1 - 2018/7/11

N2 - Ferretti et al. use metagenomics with strain-resolved computational profiling to characterize the transfer of microbes from mothers to their infants during their first 4 months of life. Multiple maternal body sites contribute to the developing infant microbiome, with maternal gut strains providing the largest contribution of colonizing microorganisms.

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KW - infant microbiome

KW - microbiome transmission

KW - shotgun metagenomics

KW - strain-level profiling

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AN - SCOPUS:85049110253

SN - 1931-3128

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ER -

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Abstract

Bibliographical note

Keywords

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