Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Pamela Ferretti, Edoardo Pasolli, Adrian Tett, Francesco Asnicar, Valentina Gorfer, Sabina Fedi, Federica Armanini, Duy Tin Truong, Serena Manara, Moreno Zolfo, Francesco Beghini, Roberto Bertorelli, Veronica De Sanctis, Ilaria Bariletti, Rosarita Canto, Rosanna Clementi, Marina Cologna, Tiziana Crifò, Giuseppina Cusumano, Stefania GottardiClaudia Innamorati, Caterina Masè, Daniela Postai, Daniela Savoi, Sabrina Duranti, Gabriele Andrea Lugli, Leonardo Mancabelli, Francesca Turroni, Chiara Ferrario, Christian Milani, Marta Mangifesta, Rosaria Anzalone, Alice Viappiani, Moran Yassour, Hera Vlamakis, Ramnik Xavier, Carmen Maria Collado, Omry Koren, Saverio Tateo, Massimo Soffiati, Anna Pedrotti, Marco Ventura, Curtis Huttenhower, Peer Bork, Nicola Segata*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

719 Scopus citations

Abstract

Ferretti et al. use metagenomics with strain-resolved computational profiling to characterize the transfer of microbes from mothers to their infants during their first 4 months of life. Multiple maternal body sites contribute to the developing infant microbiome, with maternal gut strains providing the largest contribution of colonizing microorganisms.

Original languageAmerican English
Pages (from-to)133-145.e5
JournalCell Host and Microbe
Volume24
Issue number1
DOIs
StatePublished - 11 Jul 2018
Externally publishedYes

Bibliographical note

Funding Information:
We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG- 716575 ), MIUR “Futuro in Ricerca” RBFR13EWWI_001 , the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant ( 707345 ) to E.P.

Funding Information:
We thank all the families enrolled in the study. This study was supported by Fondazione CARITRO fellowship Rif. Int. 2013.0239 to N.S. The work was also partially supported by the European Research Council (ERC-STG project MetaPG-716575), MIUR “Futuro in Ricerca” RBFR13EWWI_001, the People Program (Marie Curie Actions) of the European Union Seventh Framework Program (FP7/2007–2013) under REA grant agreement no. PCIG13-GA-2013-618833, the LEO Pharma Foundation to N.S., and a European Union H2020 Marie-Curie grant (707345) to E.P.

Keywords

  • infant microbiome
  • microbiome transmission
  • shotgun metagenomics
  • strain-level profiling

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