Mouse macrophage functions under the influence of factors released by spleen cells preincubated with the methanol extraction residue (MER) tubercle bacillus fraction

Ruth Gallily, Ita Stain, David W. Weiss*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Exposure of mouse peritoneal macrophages in vitro to the nonspecific immunomodulator MER (methanol extraction residue fraction of phenol killed, acetone washed tubercle bacilli) failed to heighten their phagocytic and bacteriostatic activities toward Staphylococcus albus, even when amounts of the agent below the threshold of gross toxicity were employed. In contrast, exposure of such macrophages to supernatants of whole splenocyte suspensions that has been obtained from normal donors and were incubated with MER resulted in consistent potentiation of both phagocytosis and bacteriostasis. The findings suggest that the MER effect on macrophage function is mediated, in this system, by soluble lymphocyte product(s).

Original languageEnglish
Pages (from-to)221-231
Number of pages11
JournalImmunopharmacology
Volume3
Issue number3
DOIs
StatePublished - Sep 1981

Keywords

  • (MER)
  • Bacteriostasis
  • Macrophages
  • Methanol extraction residue of tubercle bacilli
  • Phagocytosis

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