Mouse mammary tumor virus env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer

Allan Bar-Sinai; Nir Bassa; Maria Fischette; Michael M. Gottesman; Dona C. Love; John A. Hanover; Jacob Hochman

doi:10.1158/0008-5472.CAN-04-3879

Mouse mammary tumor virus env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer

Allan Bar-Sinai, Nir Bassa, Maria Fischette, Michael M. Gottesman, Dona C. Love, John A. Hanover, Jacob Hochman^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

We have previously shown that the leader peptide (p14) of the Env-precursor of mouse mammary tumor virus is translocated into the nucleoli of murine T cell lymphomas that harbor this virus. Using a polyclonal antibody against recombinant p14, we show here that p14 is also localized to the nucleoli of murine mammary carcinomas and some human breast cancer samples. Affinity purification studies define a number of proteins, mostly nucleolar, that bind p14. Taken together, these findings point towards a more general involvement of p14 in lymphomagenesis and mammary carcinogenesis.

Original language	English
Pages (from-to)	7223-7230
Number of pages	8
Journal	Cancer Research
Volume	65
Issue number	16
DOIs	https://doi.org/10.1158/0008-5472.CAN-04-3879
State	Published - 15 Aug 2005

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10.1158/0008-5472.CAN-04-3879

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abstract = "We have previously shown that the leader peptide (p14) of the Env-precursor of mouse mammary tumor virus is translocated into the nucleoli of murine T cell lymphomas that harbor this virus. Using a polyclonal antibody against recombinant p14, we show here that p14 is also localized to the nucleoli of murine mammary carcinomas and some human breast cancer samples. Affinity purification studies define a number of proteins, mostly nucleolar, that bind p14. Taken together, these findings point towards a more general involvement of p14 in lymphomagenesis and mammary carcinogenesis.",

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AU - Bar-Sinai, Allan

AU - Bassa, Nir

AU - Fischette, Maria

AU - Gottesman, Michael M.

AU - Love, Dona C.

AU - Hanover, John A.

AU - Hochman, Jacob

PY - 2005/8/15

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AB - We have previously shown that the leader peptide (p14) of the Env-precursor of mouse mammary tumor virus is translocated into the nucleoli of murine T cell lymphomas that harbor this virus. Using a polyclonal antibody against recombinant p14, we show here that p14 is also localized to the nucleoli of murine mammary carcinomas and some human breast cancer samples. Affinity purification studies define a number of proteins, mostly nucleolar, that bind p14. Taken together, these findings point towards a more general involvement of p14 in lymphomagenesis and mammary carcinogenesis.

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Mouse mammary tumor virus env-derived peptide associates with nucleolar targets in lymphoma, mammary carcinoma, and human breast cancer

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