Abstract
MPP+ and paraquat (PQ+2) are two structurally analogous and highly toxic pyridinium compounds. The mechanism of PQ+2 toxicity is best understood in the bacterial model system. While numerous studies, in a variety of systems, have indicated the causative role of free radicals and other oxygen-derived active species in PQ+2 toxicity, this question is yet unresolved in the case of MPP'. In this study we have used the E. coli model and have demonstrated that MPP+ is toxic to bacterial cells in a dose and time dependent modes. Additionally, it is shown that only in the presence of molecular oxygen, bacterial inactivation occurred. The protective effects of the chemical scavenger -mannitol -and of histidine are presented. These results are in complete accord with a free radical mechanism for MPP+ toxicity.
Original language | English |
---|---|
Pages (from-to) | 697-702 |
Number of pages | 6 |
Journal | Free Radical Research |
Volume | 13 |
Issue number | 1 |
DOIs | |
State | Published - 1991 |
Keywords
- E. coli
- Free radicals
- HPTP
- Hydrogen peroxide
- Pyridinium compounds