MPP+ toxicity in E. Coli under aerobic and anaerobic conditions

Yuval Haskel, Raphael Udassin, Mordechai Chevion*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

MPP+ and paraquat (PQ+2) are two structurally analogous and highly toxic pyridinium compounds. The mechanism of PQ+2 toxicity is best understood in the bacterial model system. While numerous studies, in a variety of systems, have indicated the causative role of free radicals and other oxygen-derived active species in PQ+2 toxicity, this question is yet unresolved in the case of MPP'. In this study we have used the E. coli model and have demonstrated that MPP+ is toxic to bacterial cells in a dose and time dependent modes. Additionally, it is shown that only in the presence of molecular oxygen, bacterial inactivation occurred. The protective effects of the chemical scavenger -mannitol -and of histidine are presented. These results are in complete accord with a free radical mechanism for MPP+ toxicity.

Original languageEnglish
Pages (from-to)697-702
Number of pages6
JournalFree Radical Research
Volume13
Issue number1
DOIs
StatePublished - 1991

Keywords

  • E. coli
  • Free radicals
  • HPTP
  • Hydrogen peroxide
  • Pyridinium compounds

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