Mucosal and Skin Langerhans Cells – Nurture Calls

Avi Hai Hovav*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Langerhans cells (LCs) are classically viewed as unique antigen-presenting cells (APCs) that originate from embryonic precursors and maintain themselves independently in the epidermis. However, recent studies have demonstrated that murine LCs in mucosal epithelia arise and are continuously replenished from circulating bone marrow (BM) precursors. This has led to the emergence of a novel perspective proposing that LCs can evolve from various origins. Because both embryonic and BM precursors differentiate into LCs only after entering the epithelium, this highlights its crucial role in nurturing LC development to perfectly comply with the physiological functions of the tissue. Thus, current evidence suggests plasticity of LC differentiation, revealing novel developmental mechanisms that are controlled by environmental cues.

Original languageAmerican English
Pages (from-to)788-800
Number of pages13
JournalTrends in Immunology
Volume39
Issue number10
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd

Keywords

  • Langerhans cells
  • epithelium
  • mucosa
  • skin

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