Multidonor bone marrow transplantation improves donor engraftment and increases the graft versus tumor effect while decreasing graft-versus-host disease

Yekhtina Zhanna, Hirshfeld Ester, Weiss Lola, Gerlitz Offer, Slavin Shimon, Michael Yechiel Shapira

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In partially matched donor transplantation, mandatory T-cell depletion (TCD) increases the risks of rejection/graft failure, relapse, and post-transplant infections. A multi-donor approach was offered to resolve some of these drawbacks. This hypothesis was previously tested in a TCD fully mismatched murine model. However, the effect of multi-donor transplantation (MDT) on graft-versus-host disease (GVHD) and graft versus tumor (GVT) effect were never tested. To assess the safety and efficacy of MDT, we used it in non-TCD transplantation and murine breast carcinoma model. We found that when transplanting non-TCD MDT composed by C57Bl/6 and C3H cells into BALB/c, a consistent trichimerism is established, dominated by C57Bl/6 cells. Following MDT the study animals experienced reduced GVHD compare with those transplanted from C57Bl/6 alone, while the GVT effect was superior. We conclude that MDT may serve as a technique that suppresses GVHD while maintaining the GVT effect.

Original languageAmerican English
Pages (from-to)194-200
Number of pages7
JournalTransplant International
Volume24
Issue number2
DOIs
StatePublished - Feb 2011
Externally publishedYes

Keywords

  • allogeneic stem cell transplantation
  • graft versus tumor effect
  • graft-versus-host disease
  • multi donors
  • safety

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