Multimodal Imaging of the Mouse Placenta

Tal Raz, Reut Avni, Michal Neeman

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Multimodal imaging is an important part of the study of placenta structure and function, as well as embryonic development, particularly in transgenic mice. The development of novel imaging techniques can contribute significantly to enhance our understanding of placental structure, exchange within the placenta, as well as the architecture and function of the maternal and fetal vasculature system, all of which are critical in the evaluation of the dynamic relationships between the mother, placenta, and fetus during pregnancy. Recent progress of a number of imaging approaches is described herein, including non-invasive MRI, ultrasound imaging, fluorescence microscopy, and photoacoustic imaging. Applications of these techniques are used to monitor the details of blood-flow patterns in the uterine arteries, to measure placental perfusion, and to characterize angiogenesis and vascular permeability, providing insight into placental and fetal pathologies. All of these findings eventually provide a better appreciation for the unique properties of mammalian development and reproduction.

Original languageAmerican English
Title of host publicationThe Guide to Investigation of Mouse Pregnancy
PublisherElsevier
Pages363-372
Number of pages10
ISBN (Electronic)9780123944450
ISBN (Print)9780123947949
DOIs
StatePublished - 1 Jan 2014

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc. All rights reserved.

Keywords

  • Bioluminescence reporter gene
  • Intravital Fluorescence Microscopy
  • Magnetic Resonance Imaging (MRI)
  • Multimodal imaging
  • Optical Imaging
  • Perfusion
  • Photoacoustic tomography
  • Ultrasound
  • Uterine vasculature

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